The String Cheese Incident opened up the first set with “Outside Inside”, getting the rowdy hometown crowd on their feet out of the gates. Bill Nershi and Michael Kang traded off some firey hot licks, as Keith “Moose” Moseley held down the low end with a bubbly groove. With Kang hopping over to fiddle, the familiar opening segment of “Bollymuster” rang out, igniting a full-fledged dance party while the night was still extremely young. Encore: Good Times Around the Bend Setlist: The String Cheese Incident | 1STBANK Center | Broomfield, CO | 12/31/2018 A highlight of the evening was “Rollover”, as the band threw in a verse of Queen’s “Bohemian Rhapsody”, before setting the gearshift in to deep improvisational territory. The deep improvisational momentum reminded for the remainder of the evening, as Cheese let it all hang out with a well-calculated “The Big Reveal”, chock-full of explosive Michael Kang solos. With time running down, SCI dove into a cover of the Talking Heads‘ “This Must Be The Place”, before dropping back into “Rollover” to close the jam played earlier, and bring their well-executed New Year’s Eve extravaganza. The old-school “Good Times Around The Bend” served as the evening’s encore, leaving fans with a sweet a savory taste for what’s to come in the band’s upcoming 2019 25th anniversary concerts. Set Two: Into the Blue^, Let’s Go Outside, One Step Closer, Windy Mountain > Sirens, Best Feeling > Rosie With 15 minutes left of 2018, The String Cheese Incident came back onstage with a Bill Nershi initiated “Group Hoot”, inviting the crowd to yell at the top of their lungs for a good minute. The band moved forward with “Colliding”, a perfect selection to ramp up the energy heading into 2019. With theatrical performers and dancers on stage, life-size inflatable dolphins, and balloons galore, Cheese finally brought the raucous jam to a close, wishing their crowd a happy new year and thanking them for their continuous support over their illustrious 25-year career. For a full list of upcoming String Cheese Incident tour dates and ticketing information, head to the band’s website here. On Monday night, The String Cheese Incident returned to Broomfield, CO’s 1STBANK Center to close out their three-night New Year’s run with a stellar three-set grand finale. The band crushed it their first two shows of the run, highlighted by some standout collaborative moments with fiddle masters Sam Bush and Darol Anger, followed by Robert Randolph, Ivan Neville, Ian Neville, and Tony Hall the following night. Set One: Outside Inside > BollyMunster, Gone Crooked, MLT > My One & Only, Joyful Sound > Tom Sawyer* The bluegrass number “Gone Crooked” was up next, before bringing the salsa-influenced “MLT”, continuing to feed off of the crowd’s percolating energy on an extremely frigid and snowy Colorado night. The sextet continued trucking forward with the sweet and smooth “My One And Only” off of 2017’s Believe. Kyle Hollingsworth, Kang, and Nershi shined with some tender vocal harmonies, allowing Moseley to take the vocal lead moving into “Joyful Sound”. Following a feel-good “Joyful Sound”, the Barefoot Boys brought the first set to a close with a rocking cover of Rush’s “Tom Sawyer”, last played at Red Rocks Amphitheatre in 2015. Set Three: Group Hoot, Colliding > Happy New Year, Rollover > Bohemian Rhapsody verse > The Big Reveal, This Must Be the Place > Rollover *: Rush cover, LTP 07-26-15^: FTP, SCI Sound Lab debutLoad remaining images SCI got creative with their second set opener, as the band debuted “Into The Blue”, a new tune out of their SCI Sound Lab. The crowd showered the hometown heroes with applause and their upmost attention. Hollingsworth then led his bandmates into “Let’s Go Outside”, before Nershi took the reigns on his Fender Telecaster, unleashing an electrifying solo as Hollingsworth followed closely behind. A standard take on “One Step Closer” followed, before the six-piece moved forward with a smoothly-segued one-two combo of “Windy Mountain” and “Sirens”. Love and light was flowing throughout the 1STBANK Center as the band belted out, “I just wanna say I love you, and make sure you feel it everyday.” The band kept on chugging forward with “Best Feeling”, before bringing wrapping up set two with “Rosie”, as lighting designer Andrew Cass showcased his visual magic, taking the band to a fifth, extraterrestrial dimension.
Researchers at the Harvard Stem Cell Institute (HSCI) have shown that a protein, which they previously demonstrated can make failing hearts in aging mice appear more like those of young and healthy mice, similarly improves brain and skeletal muscle function in aging mice.In two papers released online early today by the journal Science (which will formally publish the papers on Friday), professors Amy Wagers and Lee Rubin of Harvard’s Department of Stem Cell and Regenerative Biology (HSCRB) report that injections of a protein known as GDF11, which is found in humans as well as mice, improved the exercise capability of mice and improved function of the olfactory region of the brains in the older mice.Rubin and Wagers, who also has a laboratory at the Joslin Diabetes Center, said that, barring unexpected developments, they expect to have GDF11 enter initial human clinical trials within three to five years.Postdoctoral fellow Lida Katsimpardi is the lead author on the Rubin group’s paper, and fellows Manisha Sinha and Young Jang are the lead authors on the paper from the Wagers group.The studies examined the effect of GDF11 in two ways. First, they used a parabiotic system, in which two mice are surgically joined and the blood of the younger mouse circulates through the older mouse. Second, they injected the older mice with GDF11, which in an earlier study by Wagers and Richard Lee of Brigham and Women’s Hospital was shown to be sufficient to reverse characteristics of aging in the heart. Lee is also an author on the two new papers.Doug Melton, co-chair of HSCRB and co-director of HSCI, reacted to the papers’ findings by saying he could not recall “a more exciting finding to come from stem cell science and clever experiments. This should give us all hope for a healthier future.“We all wonder why we were stronger and mentally more agile when young. And these two unusually exciting papers actually point to a possible answer: the higher levels of the protein GDF11 we have when young. There seems to be little question that, at least in animals, GDF11 has an amazing capacity to restore aging muscle and brain function,” he said.Melton, Harvard’s Xander University Professor, said the ongoing collaboration among Wagers, a stem cell biologist whose focus has been on muscle, Rubin, a neurobiologist whose focus has been on neurodegenerative diseases and using patient-generated stem cells as targets for drug discoveries, and Lee, a practicing cardiologist and researcher, “is a perfect example of the power of the Harvard Stem Cell Institute as an engine of truly collaborative efforts and discovery, bringing together people with big, unique ideas and expertise in different biological areas.”As Melton mentioned, GDF11 is naturally found in much higher concentrations in younger mice than in older ones, and raising its level in older mice has improved function of every organ system studied so far.Wagers first used the parabiotic system in mice 14 years ago as a postdoctoral fellow at Stanford University, when she and colleagues Thomas Rando and Irving Weissman of Stanford, and Irina Conboy of the University of California, Berkeley, observed that the blood of young mice circulating in old mice seemed to have some rejuvenating effects on muscle repair after injury.Last year, she and Lee published a paper in which they reported that, when exposed to the blood of young mice, the enlarged, weakened hearts of older mice returned to a more youthful size, and their function improved. Working with a Colorado firm, the pair reported that GDF11 was the factor in the blood apparently responsible for the rejuvenating effect. That finding raised hopes that GDF11 may prove, in some form, to be a possible treatment for diastolic heart failure, a condition in the elderly that is irreversible, and fatal.“From the previous work, it could have seemed that GD11 was heart-specific,” said Wagers, “but this shows that it is active in multiple organs and cell types … Prior studies of skeletal muscle and the parabiotic effect really focused on regenerative biology. Muscle was damaged and assayed on how well it could recover.“The additional piece is that while prior studies of young blood factors have shown that we achieve restoration of muscle stem cell function, and they repair the muscle better, in this study we also saw repair of DNA damage associated with aging. And we got it in association with recovery of function. And we saw improvements in unmanipulated muscle. Based on other studies, we think that the accumulation of DNA damage in muscle stem cells might reflect an inability of the cells to properly differentiate to make mature muscle cells, which is needed for adequate muscle repair.”Wagers noted that there is still a great deal to be learned about the mechanics of aging in muscle, and its repair. “I don’t think we fully understand how this is happening or why. We might say that the damage is modification to the genetic material; the genome does have breaks in it. But whether it’s damaging, or a necessary part of repair, we don’t know yet.”Rubin, who works on developing treatment for neurodegenerative diseases, particularly in children, said that when his group began its GDF11 experiments, “We knew that, in the old mouse, things were bad in the brain, there is a reduced amount of neurogenesis [the development of neurons], and it’s well known that cognition goes down. It wasn’t obvious to me that those things that can be repaired in peripheral tissue could be fixed in the brain.”Rubin said that Katsimpardi was taught the parabiotic experimental technique by Wagers, but conducted the Rubin group’s experiments independently of the Wagers group, and “she saw an increase in neural stem cells, and saw increased development of blood vessels in the brain.” Rubin said that 3-D reconstruction and magnetic resonance imaging (MRI) of mice brains showed “more new blood vessels and more blood flow, both of which are normally associated with younger, healthier brain tissue.”Younger mice, Rubin said, “have a keen sense of olfactory discrimination.” They can sense fine differences in odor. “When we tested the young mice, they avoided the smell of mint; the old mice didn’t. But the old mice exposed to the blood of the young mice, and those treated with GDF11, did.“We think an effect of GDF 11 is the improved vascularity and blood flow, which is associated with increased neurogenesis,” Rubin said. “However, the increased blood flow should have more widespread effects on brain function. We do think that, at least in principle, there will be a way to reverse some of the cognitive decline that takes place during aging, perhaps even with a single protein. It could be that a molecule like GDF 11, or GDF 11 itself, could” reverse much of the damage of aging.“It isn’t out of the question that GDF11,” or a drug developed from it, “might be capable of slowing some of the cognitive defects associated with Alzheimer’s Disease, a disorder whose main risk factor is aging itself,” Rubin said. It is even possible that this could occur without directly changing the “plaque and tangle burden” that is the pathological hallmark of Alzheimer’s. Thus, a future treatment for this disease might be a combination of a therapeutic treatment that reduces plaques and tangles, such as an antibody directed against the β-amyloid peptide, with a potential cognition enhancer like GDF-11.Wagers said that the two research groups are in discussions with a venture capital group to obtain funding to “be able to do the additional preclinical work” necessary before taking GDF 11 into human trials.
Reflecting its decades-long commitment to confronting climate change, Harvard University was one of four inaugural members of Boston Mayor Martin Walsh’s Carbon Cup, which launched Saturday, May 31, 2014. By opting into the challenge Harvard, Boston University, Massachusetts General Hospital, and Brigham & Women’s Hospital have collectively agreed to commit roughly 15 million square feet to the cup with the hopes of removing approximately 35,000 metric tons of GHC from a 2005 baseline, equivalent to weathering close to 27,000 housing units.From creating new materials that revolutionize solar energy production, to probing the human influences on climate change and providing analysis to policymakers, Harvard faculty and students are playing key roles in the transition to renewable energy sources and a more sustainable future.In addition to its research and teaching in this area, Harvard is committed to modeling an institutional pathway toward a more sustainable future. In 2008, President Faust and the deans approved a goal to reduce greenhouse gas emissions 30% by 2016, including growth, from a 2006 baseline. From fiscal year 2006 to fiscal year 2013 University-wide emissions have dropped 21% including growth and renovation and 31% when growth is excluded. Read Full Story
Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York Dozens of women clad in red rallied in the shadow of Roosevelt Field Mall in Garden City on Wednesday for International Women’s Day and to raise awareness about a range of issues, including paid leave, reproductive rights and equal pay.Attendees chanted, “Equal pay for equal work!” and “My body, my choice!” while waving signs proclaiming, “We are the 51 percent”—a reference to the majority-female population in the United States—and endorsing Planned Parenthood, as cars zoomed passed on Old Country Road and honked in support.Nassau County Legis. Laura Curran (D-Baldwin), who is running for county executive in the November election, told the women alongside her that she wanted to inspire others to get involved.“The Old Boys Club has been running Nassau County for far too long,” she said through a megaphone, noting that only four of the 23 elected seats in the county are held by women. “I’m running to change that.”The South Shore Women’s Caucus, a grassroots group that grew out of protests stemming from President Donald Trump’s election, organized the rally, which also coincided with a parallel day of action called “A Day Without A Woman”—the essence of which was to shine a light on the importance of women in the economy.Democrats have been clearly disappointed with the November election results, and thousands nationwide have responded to Trump’s ascension with acts of civil disobedience and grassroots political action. Several women Wednesday said they attended Women’s Marches a day after Trump’s inauguration and have continued to be politically active ever since.The event on a sunny but breezy Wednesday in Garden City drew about 50 women, some coming as far as the Hamptons, and ranged from high school and college-aged women to parents of young children and retirees.While many shared individual concerns, their motivations for demonstrating were to highlight the role of women in society and issues they consider pressing.“I need to protect women’s rights, I need to protect Planned Parenthood, I need to protect Obamacare,” said a woman named Audrey, a member of the Bellmore-Merrick Democratic Club, who didn’t want to give her last name. “Before this election, there were many times when we only had about a dozen people attending our meetings. And since this election, people are so upset that we’ve been having over 100 people attending our meetings. People want to get involved.”Halle Brenner, 47, of East Northport, brought along her daughter, a junior in high school, who felt compelled to rally alongside her mom.“I just feel like so many of my values and many American values are under attack by this administration and, quite frankly, the Republican Party also,” Brenner said, mentioning various issues, including minimum wage and equal pay.“It’s amazing to me that my daughter still has to fight for that,” she added.Brenner said she was concerned about the impact the new administration’s policies would have on Planned Parenthood, which is in danger of losing funding as part of a Republican-led health care overhaul, adding that the group predominantly conducts preventive tests that don’t draw as much attention as its abortion procedures, such as mammograms and pap smears.Shane Larkin, public affairs coordinator for Planned Parenthood of Nassau County, said women have the power to make a difference.“Right now we need to embody resistance, strength and leadership; and we’re also acknowledging all the women who possess those qualities who we can’t go a day without,” she said.For Abby Roden, 19, of East Hampton, the 80-mile journey west was necessary to send a message that her generation is up to the task of continuing the fight for women’s rights that began decades ago.Roden, a freshman in college home for spring break, recalled a conversation she had once with Gloria Steinem in which the feminist icon said: “I don’t need to pass the torch but I’m just going to light all of yours.”That has stuck with her.“It is so important for us to get involved, and I’ve always felt that way,” she said. “I’m tired of people saying that our generation doesn’t care.”For Joy Hutchins, 38, of Merrick, attending Wednesday’s rally was her way of passing the torch.“I have three children: two daughters and a son. I want them to know how important women’s rights are. I want them to have rights over their own bodies,” she said. “I don’t think it belongs in politics.”Hutchins brought along her 3-year-old son, who looked on from his stroller.“He has to learn how to treat women right,” she said.Holding the rally just feet from the entrance of Roosevelt Field Mall had its own kind of symbolism, especially on a day when women’s rights activists encouraged others to strike or refrain from shopping.“Women are important in this economy. We are the shoppers,” said Beverly Visconti, of Baldwin. “If we don’t go to the stores, nothing goes. And we are trying to make a statement that we are important in this society.”Events celebrating International Women’s Day were planned across the globe Wednesday.Gov. Andrew Cuomo said the day held extra significance because 2017 marks the 100th anniversary of women’s suffrage in New York State.“Rest assured, New York will not waiver in our commitment to women’s rights, and we will stand tall with all women to move our progress forward,” Cuomo said.
802SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Shane Snow Shane Snow is an award-winning journalist and entrepreneur, and the bestselling author of Smartcuts: How Hackers, Innovators, and Icons Accelerate Success. He is the Chief Creative Officer of Contently, which … Web: www.shanesnow.com/bio Details I talk a lot about the idea of lateral thinking – the art of approaching problems from new or non-obvious directions. It’s like thinking outside of the box – but a better way to imagine it involves a chocolate cake. Imagine you’re hosting seven friends and you need to split a round cake eight ways. But there’s a catch: you can only cut the cake three times. What do you do?If you answered “Turn the cake on its side, cut through the middle, and then two more slices across the top make eight pieces” … then you know what I’m talking about.There are a host of problems and challenges facing credit unions today that could benefit from that kind of lateral thinking. One of the challenges is that the times are changing, and a new generation is requiring your services: millennials.I’m often asked what makes millennials – my generation – different. The main things are: they’re younger, and they grew up with more technology. In many ways, millennials are not very different from other generations. We all grow up and get old and have remarkably similar life challenges and phases. But because of technology, we communicate differently, and we’re used to having more say in who we interact with, do business with, buy from and buy into. We also do more research and make use of platforms for finding information on demand – rather than relying on the crutch of memorization.As corny as it sounds, credit union leaders need to remember that they were young once, too, and of course they were smart and discerning back then too. There’s a temptation to pigeonhole millennials as bratty or dumb – but kids are smart. Our grandparents thought our parents were bratty when they were in their teens and 20s, too.With that said, the most important thing to remember when attracting and retaining digital-savvy members is that consumers have a lot more power than before, and information asymmetry is now on their side. They can – and will – do a lot of research before making a decision. And because they have more options, they’re going to buy from companies they can buy into. This means that authenticity, congruence (being who you say you are), values and a good story are more important than ever before. Marketing today is more about storytelling and relationship-building than it is about salesmanship.But what do millennials want? What are the lending opportunities there?The obvious answer is there are a whole lot of millennials who are about to start buying houses and having kids and becoming leaders in companies – and making more income. The opportunity, as I see it, is to show them that credit unions are more than just another banking option: they’re a smarter option, and the more do-gooder option (for lack of a better term) – which is a highly valuable trait for businesses in a social media world.My advice for credit unions is the same advice I give to all businesses: Tell great stories. Great stories build relationships and make people care. Tell the stories of the people in your communities that you care about, and tell the stories of the community itself. There’s no reason a credit union in Idaho Falls, Idaho, can’t become a regular and appreciated presence on community members’ Instagram feeds – telling the stories of the members they serve.I’ll be talking more about telling stories and lateral thinking – as well as my thoughts on how credit unions can be innovators – at NAFCU’s Strategic Growth Conference from March 8-10 in San Diego. I hope to see you there so we can map out the next steps for your credit union and community!
College is generally not a surprise. From the time your children are born, if you suspect they’re going to go to college—and about 68% of high school graduates do—you have 18 years to plan for it.And yet, only two in five families with kids in college made a plan to pay for it, according to Sallie Mae’s most recent How America Pays for College report—and that number that hasn’t changed significantly since 2010 when Sallie Mae started asking the question.By “planning,” the report talks about researching types of schools, thinking about how much everything will cost, considering what resources the family might be able to throw toward college expenses and setting goals. And planning ups your chances of success substantially. Families with plans generally end up being able to put more money toward college and their students borrow a third less money than families without plans. continue reading » 13SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
By Greg AregoniFRANCIS CREEK, Wis. (May 9) – Van Pay is a name that has numerous feature wins and a name that is highly regarded in the area racing family.A new Van Pay has put his own tally in the win column after the Karl Chevrolet Northern SportMod feature Saturday night at 141 Speedway. Race Van Pay joined the ranks of feature winners earning his first career win in a highly contested race.All 20 laps of the feature belonged to Van Pay, who had his share of challengers along the way but held all of them at bay.A three-lap dash to the finish was the final test that Van Pay passed. He stayed true to his line and picked up his first career feature win.Shawn Kilgore won again in the IMCA Xtreme Motor Sports Modifieds after starting 10th. Devin Snellenberger, who got on his roof last week, dominated the IMCA Sunoco Stock Car feature.Shaun Bangart gained the lead with three laps left and won the Mach-1 Sport Compact main event.
Press Association “It is too early. They are not out of the title race,” Wenger said. “We are only two points in front of all the others. “Are Man United out of the title race? No, but of course 10 points starts to be a little gap.” Wenger continued: “If you have the choice, you want to be in the race at the top, but you cannot rule Man United out today. “They have big players, big experience and they are a big club. “It (points advantage) is three games basically, that is very quick in our league.” Wenger has a wealth of options in midfield, with the return to match fitness of Santi Cazorla following an ankle injuring meaning Aaron Ramsey could be rested to the bench against Norwich. The Wales international replaced Mathieu Flamini just before half-time after the French midfielder suffered double vision following a clash of heads with Alex Tettey and is now a doubt for Tuesday night’s Champions League game against Borussia Dortmund as a result. Arsenal manager Arsene Wenger is not about to write off Manchester United’s Barclays Premier League title challenge just yet. Wenger knows he will need to fully utilise the group if Arsenal are to mount a sustained push for honours in 2014. “We have a squad that is, number and quality wise, very, very good. After that in January we are not desperate (to buy) now,” the Arsenal boss said. “If there is a good opportunity (to buy), why not? But if you know who is out injured now, they will come back in November, the beginning of December, then you have a really massive squad.” Wenger added: “With the number of competitions involved, everybody thinks they have a chance to play. That is what is the most important. “As long as you fight for things, everybody keeps the focus.” Wenger revealed England forward Theo Walcott would need a couple more weeks of recovery time following a minor surgical procedure on an abdominal problem. “Theo had a set-back on Thursday. He had to stop, to jog again, I don’t think we will see him against Dortmund, nor Crystal Palace nor Chelsea (in the Capital One Cup),” the Arsenal boss said. “He is at least two weeks away now.” The Gunners moved clear at the top of the table following their 4-1 victory over Norwich and are now some eight points ahead of David Moyes’ side after the Red Devils conceded a late equaliser at home to Southampton. Wenger, though, is refusing to get carried away with league positions just yet, as Arsenal are set to travel to Old Trafford next month the weekend after they host fellow pacesetters Liverpool.
Rio de Janeiro, May 5: Grief-stricken Brazilian football club Chapecoense has received a grant from the Brazilian government to help upgrade its stadium. President Michel Temer on Thursday pledged $5 million in public funds to the project, which previews the redevelopment of the southern and western stands of Are Conda, in the southern Brazilian city of Chapeco.Seventy-one people died, including 19 Chapecoense players and all of their coaching staff, when the LaMia charter plane in which the team was traveling slammed into a hillside near Medellin, Colombia, last November. There were just six survivors, reports Xinhua news agency.“The team no longer belongs just to this city, but to the world,” Chapeco Mayor Luciano Jose told reporters on Thursday. “Starting with the solidarity shown by Colombia, Chapecoense has become dear to all of Brazil and the world.”The stadium refurbishment plans include provision for a new museum, featuring a memorial section paying homage to victims of the air disaster.Officials said the venue’s current capacity of around 23,000 spectators would be maintained. IANS
By Steve KeatingDOHA, Qatar (Reuters) – Guinea-Bissau’s Braima Dabo will not win any medals at the world championships but he won the admiration of the crowd yesterday by helping exhausted Aruban Johnathan Busby across the 5 000 metres finish line in an astonishing display of sportsmanship.It was an agonising and heartwarming end to the opening heat of the men’s 5 000m as a distressed Busby, near collapse, was rescued on the final lap by Dabo and helped home, with the two men crossing the line to a rousing ovation at Khalifa Stadium.“The main objective was to represent my country as well as possible and I’m happy I could help the other guy,” Portuguese-speaking Dabo told Reuters. “I saw he was not running in the right way, he was leaning, I realised he wasn’t going to finish.“I knew I wasn’t going to beat my personal record, so when I realised that, it was better to go for the main aim, which was to finish the race. My thoughts were to help him finish, that is the point of the race.”Despite the searing temperatures in Doha, the race was run in pleasant spring-like conditions thanks to the innovative air-conditioning system at the Khalifa stadium.The heat was won by Ethiopia’s Selemon Barega in a time of 13 minutes 24.69 seconds but it was the heroic effort unfolding behind the winner that brought the crowd to its feet.As the pair crossed the finish line nearly five minutes later, Dabo held Busby until emergency personnel appeared, with the Aruban put in a wheelchair and taken from the track.There was no immediate word on 33-year-old Busby’s condition.“He thanked me and he was suffering, he couldn’t really speak … in any case, we don’t speak the same language so our conversation was never going to be very long,” said Dabo.Asked about the crowd’s reaction to his gesture of sportsmanship a humble Dabo, 26, said nothing had changed.“I continue being the same as before – I’m proud to be here representing my country.”